Latha Satish, MSc, MPhil, PhD

Research Assistant Professor of Plastic Surgery
Latha Satish, MSc, MPhil, PhD - headshot

Contact

412-427-9625
Fax: 412-648-2821

1649 E BST

200 Lothrop Street

Pittsburgh, PA 15261, 

Biography

Dr. Satish joined the Department of Plastic Surgery at the University of Pittsburgh Medical Center as a Research Assistant Professor in July 2011.  She obtained her undergraduate, postgraduate and doctoral degrees at the University of Madras, Chennai, India. Dr. Satish then completed her formal postdoctoral training at the University of Pittsburgh with her advisor, Dr. Alan Wells, Vice Chairman of UPMC’s Department of Pathology. MD. She then joined Dr. Sandeep Kathju at the Center for Genomic Sciences at Allegheny General Hospital, first as a Research Associate and then as Research Assistant Professor.  

Dr. Satish continues to collaborate with Dr. Kathju to investigate the genes that are responsible for scarless wound healing, aiming ultimately to modulate the genes in adult wounds to mitigate scar formation. A related research interest is to study various biological means by which palmar fascia fibrosis (Dupuytren’s contracture) might be reduced. A third area of interest is the importance of bacterial biofilms in clinical disease, especially in problems of wound healing. Dr. Satish has won academic awards and has written dozens of peer reviewed articles, reviews and book chapters primarily on skin wound healing, skin fibrosis and Dupuytren’s contracture. Satish also serves as a mentor for Pittsburgh Tissue Engineering Initiative (PTEI) summer interns and participates in teaching high school and undergraduate students the significance of laboratory research in science.

Publications

Satish L, LaFramboise WA, Johnson S, Vi L, Raykha C, Krill-Burger JM, Gallo, PH, O’Gorman DB, Gan BS, Baratz ME, Ehrlich GD, Kathju S. Fibroblasts from phenotypically normal palmar fascia exhibit molecular profiles highly similar to fibroblasts from active disease in Dupuytren's Contracture. BMC Medical Genomics. 2012 May 4;5:15. | View Abstract »

Gallo PH, Satish L, Johnson S, Kathju S. Increased expression of Ero1L-alpha in healing fetal wounds. BMC Research Notes 2011. Jun 6;4:175. | View Abstract »

Satish L, Lo N, Gallo PH, Johnson S, Haberman S, Kathju S. Chaperonin containing T-complex polypeptide (CCT) subunit expression in oral mucosal wounds and fibroblasts. Cell Stress and Chaperones. 2011. Nov;16 (6):675-80. Epub 2011 Jun 28. | View Abstract »

Satish L, Gallo PH, Baratz ME, Johnson S, Kathju S. Reversal of TGF-beta1 stimulation of alpha-smooth muscle actin and extracellular matrix components by cyclic-AMP in Dupuytren's-derived fibroblasts. BMC Musculoskeletal Disorders. 2011. May 25;12:113. | View Abstract »

Kathju S, Lasken RS, Satish L, Johnson S, Stoodley P, Post JC, Ehrlich GD. Multiple displacement amplification as an adjunct to PCR-based detection of S. Aureus in synovial fluid. BMC Research Notes 2010. Oct 13;3:259. | View Abstract »

Satish L, Johnson S, Wang JH, Post JC, Ehrlich GD, Kathju S. Chaperonin containing T-complex polypeptide subunit eta (CCT-eta) is a specific regulator of fibroblast motility and contractility.PLoS One. 2010. 20;5(4):e10063. | View Abstract »

Satish L, Johnson S, Abdulally A, Post JC, Ehrlich GD, Kathju S. Cloning and expression of rabbit CCT subunits eta and beta in healing cutaneous wounds. Cell Stress and Chaperones. 2010. 15 (6): 819-826. | View Abstract »

Satish L, Hogg J, Johnson S, Oswald D, Post JC, Ehrlich GD and Kathju S. Expression of RACK1 in healing skin and mucosal wounds.Annals of Plastic Surgery. 2010. 64: 238-241. | View Abstract »

Vi L, Feng L. Zhu RD, Wu Y, Satish L, Gan BS, O’Gorman DB. Periostin differentianlly induces proliferation, contraction and apoptosis of primary Dupuytren’s disease and adjacent palmar fascia cells. Experimental Cell Research. 2009. 315: 3574-3586. | View Abstract »

Satish L, Abdulally A, Oswald D, Johnson S, Hu FZ, Post JC, Ehrlich GD, Kathju S. Differential Expression of Chaperonin Containing T-Complex Polypeptide (CCT) Subunits During Fetal and Adult Skin Wound Healing. Cell Stress and Chaperones. 2008.13: 527-533. | View Abstract »

Satish L, Laframboise WA, Gorman DB’O, Johnson S, Janto B, Gan BS, Baratz ME, Hu FZ, Post JC, Ehrlich GD and Kathju S. Identification of Differentially Expressed Genes in Fibroblasts Derived from Patients with Dupuytren’s Contracture. BMC Medical Genomics. 2008.Apr 23:1:10. | View Abstract »

Kathju S, Satish L, Rabik C, Rupert T, Oswald D, Johnson S, Hu FZ, Post JC and Ehrlich GD. Identification of differentially expressed genes in scarless wound healing utilizing PCR suppression subtractive hybridization. Wound Repair and Regeneration. 14: 413-4. | View Abstract »

Satish L, Weiler JL and Wells A. Gene expression patterns in isolated keloid fibroblasts. Wound Repair and Regeneration. 14: 463-470. | View Abstract »

Satish L, Blair HC, Glading A and Wells A. Interferon-inducible protein 9 (CXCL11)-induced cell motility in keratinocytes requires calcium flux-dependent activation of mu-calpain. Molecular and Cellular Biology. 2005. 25:1922-1941. | View Abstract »

Satish L, Yager D and Wells A. Glu-Leu-Arg-negative CXC chemokine interferon gamma inducible protein-9 as a mediator of epidermal-dermal communication during wound repair. Journal of Investigative Dermatology. 2003. 120: 1110-1117. | View Abstract »